Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …

Hypoxia, a prevalent characteristic of most solid malignant tumors, contributes to diminished
therapeutic responses and more aggressive phenotypes. The term hypoxia has two …

PURPOSE: Tumor hypoxia plays a fundamental role in tumor progression and treatment
resistance. Recent evidence that hypoxia also influences the regulation and transcription of …

Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Significance: Most solid tumors contain regions of low oxygenation or hypoxia. Tumor
hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor …

Tumor hypoxia is a hallmark of solid malignant tumor growth, profoundly influences
malignant progression and contributes to the development of therapeutic resistance …

Areas of reduced oxygenation (hypoxia) have been identified in most solid tumours. Viable
tumour cells can exist under such conditions and are known to be a source of resistance to …

Hypoxia has long been recognized to influence solid tumor response to therapy.
Increasingly, hypoxia has also been implicated in tumor aggressiveness, including growth …

A growing appreciation for the importance of hypoxia in tumor progression and response to
treatment has driven efforts to develop methods that could be used routinely in the clinic to …

Tumor regions that are transiently or chronically undersupplied with oxygen (hypoxia) and
nutrients, and enriched with acidic waste products, are common due to an abnormal and …