The use of targeted toxins in research applications has recently grown considerably. The
ability to remove a few specific cells, even when surrounded by different populations, has …

Molecular neurosurgery can be used to make selective neural lesions by targeting
cytotoxins to specific populations of neurons based on their common expression of a …

Targeted toxins represent an invaluable tool offering a wide range of potential applications,
both in experimental models and in the clinics. Here we will review several aspects related …

Immunotoxins are being tested for the therapy of systemic cancer and brain tumors.
Neurotoxicity has been dose limiting for several of these antibody conjugates given …

This chapter describes the use of antineuronal immunotoxins to make selective neural
lesions. The immunotoxin approach (immunolesioning) has significantly advanced the art of …

Immunotoxins, that is conjugates of enzymatically active toxins with antibodies against cell
surface antigens, are being used in targeted cell destruction. The directed toxin enters the …

When conjugated with antibodies that bind selectively to tumor cells, natural toxins from
plants and bacteria represent a potentially powerful form of cancer therapy. Over the last …

The clinical application of immunotoxins is still hampered by a number of unsolved
problems. These include difficulties associated with each of the components of the …

INTRODUCTION lmmunotoxins are toxins with altered receptor specificity. The alteration is
achieved by coupling a monoclonal antibody to the toxin or to a toxin fragment.' …

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this
report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation …