Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma
Y Qian, Y Gong, Z Fan, G Luo, Q Huang… - Journal of hematology & …, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …
Translational advances in pancreatic ductal adenocarcinoma therapy
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is most frequently
detected at advanced stages, limiting treatment options to systemic chemotherapy with …
detected at advanced stages, limiting treatment options to systemic chemotherapy with …
New treatment strategies for metastatic pancreatic ductal adenocarcinoma
RR Singh, EM O'Reilly - Drugs, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at an advanced stage,
with systemic therapy being the mainstay of treatment. Survival continues to be limited …
with systemic therapy being the mainstay of treatment. Survival continues to be limited …
Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future
ES Christenson, E Jaffee, NS Azad - The Lancet Oncology, 2020 - thelancet.com
Pancreatic ductal adenocarcinoma is the seventh leading cause of cancer death worldwide
with an estimated 432 242 deaths occurring in 2018. This estimate, in conjunction with the …
with an estimated 432 242 deaths occurring in 2018. This estimate, in conjunction with the …
SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …
Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategies
M Chiaravalli, M Reni, EM O'Reilly - Cancer treatment reviews, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy with an overall 5-year
survival of 8% for all stages combined. The majority of patients present with stage IV disease …
survival of 8% for all stages combined. The majority of patients present with stage IV disease …
Therapeutic developments in pancreatic cancer
ZI Hu, EM O'Reilly - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most
lethal human malignancies. Much is known regarding the biology and pathophysiology of …
lethal human malignancies. Much is known regarding the biology and pathophysiology of …
Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC)
S Chandana, HM Babiker… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Prognosis remains dismal for pancreatic ductal adenocarcinoma (PDAC).
Genomics and proteomics have depicted heterogeneity in PDAC. Collectively, this …
Genomics and proteomics have depicted heterogeneity in PDAC. Collectively, this …
The TGF-β/Smad4 signaling pathway in pancreatic carcinogenesis and its clinical significance
S Ahmed, AD Bradshaw, S Gera, MZ Dewan… - Journal of clinical …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human cancers due to its
complicated genomic instability. PDAC frequently presents at an advanced stage with …
complicated genomic instability. PDAC frequently presents at an advanced stage with …
Pancreatic ductal adenocarcinoma: current and evolving therapies
A Adamska, A Domenichini, M Falasca - International journal of molecular …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …
the fourth leading cause of cancer-related deaths in the world. Due to the broad …