Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

Y Qian, Y Gong, Z Fan, G Luo, Q Huang… - Journal of hematology & …, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …

Translational advances in pancreatic ductal adenocarcinoma therapy

AN Hosein, SK Dougan, AJ Aguirre, A Maitra - Nature cancer, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is most frequently
detected at advanced stages, limiting treatment options to systemic chemotherapy with …

New treatment strategies for metastatic pancreatic ductal adenocarcinoma

RR Singh, EM O'Reilly - Drugs, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at an advanced stage,
with systemic therapy being the mainstay of treatment. Survival continues to be limited …

Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future

ES Christenson, E Jaffee, NS Azad - The Lancet Oncology, 2020 - thelancet.com
Pancreatic ductal adenocarcinoma is the seventh leading cause of cancer death worldwide
with an estimated 432 242 deaths occurring in 2018. This estimate, in conjunction with the …

SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma

J Dardare, A Witz, JL Merlin, P Gilson… - International journal of …, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …

Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategies

M Chiaravalli, M Reni, EM O'Reilly - Cancer treatment reviews, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy with an overall 5-year
survival of 8% for all stages combined. The majority of patients present with stage IV disease …

Therapeutic developments in pancreatic cancer

ZI Hu, EM O'Reilly - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most
lethal human malignancies. Much is known regarding the biology and pathophysiology of …

Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC)

S Chandana, HM Babiker… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Prognosis remains dismal for pancreatic ductal adenocarcinoma (PDAC).
Genomics and proteomics have depicted heterogeneity in PDAC. Collectively, this …

The TGF-β/Smad4 signaling pathway in pancreatic carcinogenesis and its clinical significance

S Ahmed, AD Bradshaw, S Gera, MZ Dewan… - Journal of clinical …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human cancers due to its
complicated genomic instability. PDAC frequently presents at an advanced stage with …

Pancreatic ductal adenocarcinoma: current and evolving therapies

A Adamska, A Domenichini, M Falasca - International journal of molecular …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …