Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses

W Chen, SS Foo, E Hong, C Wu, WS Lee, SA Lee… - Nature …, 2021 - nature.com
The most frequent fetal birth defect associated with prenatal Zika virus (ZIKV) infection is
brain calcification, which in turn may potentially affect neurological development in infants …

Zika virus induces abnormal cranial osteogenesis by negatively affecting cranial neural crest development

Y Yan, X Zhang, G Wang, X Cheng, Y Yan, Y Fu… - Infection, Genetics and …, 2019 - Elsevier
Zika virus (ZIKV) infection during gestation is deemed to be coupled to birth defects through
direct impairment of the nervous system during neurogenesis. However, in this study, our …

Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome

RS Aguiar, F Pohl, GL Morais, FCS Nogueira… - Science …, 2020 - science.org
Zika virus (ZIKV) infection during pregnancy can cause a set of severe abnormalities in the
fetus known as congenital Zika syndrome (CZS). Experiments with animal models and in …

Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly

I Gladwyn-Ng, L Cordón-Barris, C Alfano… - Nature …, 2018 - nature.com
Accumulating evidence support a causal link between Zika virus (ZIKV) infection during
gestation and congenital microcephaly. However, the mechanism of ZIKV-associated …

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

H Retallack, E Di Lullo, C Arias… - Proceedings of the …, 2016 - National Acad Sciences
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development
constitute a global health emergency. Congenital ZIKV infection produces a range of mild to …

Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage

Q Shao, S Herrlinger, SL Yang, F Lai… - …, 2016 - journals.biologists.com
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic …

Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain

D Limonta, J Jovel, A Kumar, J Lu, S Hou… - The Journal of …, 2019 - academic.oup.com
Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other
neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is …

Zika virus infection perturbs osteoblast function

N Mumtaz, M Koedam, PB van den Doel… - Scientific Reports, 2018 - nature.com
Zika virus (ZIKV) infection is typically characterized by a mild self-limiting disease presenting
with fever, rash, myalgia and arthralgia and severe fetal complications during pregnancy …

Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target

Z He, S An, J Chen, S Zhang, C Tan… - Proceedings of the …, 2020 - National Acad Sciences
Mounting evidence has associated Zika virus (ZIKV) infection with congenital malformations,
including microcephaly, which raises global alarm. Nonetheless, mechanisms by which …

Zika virus in the human placenta and developing brain: cell tropism and drug inhibition

H Retallack, E Di Lullo, C Arias, KA Knopp… - BioRxiv, 2016 - biorxiv.org
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development
constitute a global health emergency. Congenital ZIKV infection produces a range of mild to …