[HTML][HTML] Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
AR Williams, AD Douglas, K Miura, JJ Illingworth… - PLoS …, 2012 - journals.plos.org
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum,
which cause the symptoms and severe manifestations of malaria. We recently found that …
which cause the symptoms and severe manifestations of malaria. We recently found that …
[HTML][HTML] Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains
T Triglia, L Chen, S Lopaticki, C Dekiwadia… - PLoS …, 2011 - journals.plos.org
Plasmodium falciparum, the causative agent of the most severe form of malaria in humans
invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum …
invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum …
[HTML][HTML] A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys
AD Douglas, GC Baldeviano, CM Lucas… - Cell host & …, 2015 - cell.com
Antigenic diversity has posed a critical barrier to vaccine development against the
pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To …
pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To …
Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans
Plasmodium falciparum is an intracellular protozoan parasite that infects erythrocytes and
hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality …
hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality …
[HTML][HTML] Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum
Background A highly effective vaccine against Plasmodium falciparum malaria should
induce potent, strain transcending immunity that broadly protects against the diverse …
induce potent, strain transcending immunity that broadly protects against the diverse …
[HTML][HTML] Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies
DGW Alanine, D Quinkert, R Kumarasingha… - Cell, 2019 - cell.com
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria …
target for next-generation vaccines against the disease-causing blood-stage of malaria …
[HTML][HTML] The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria
Background Acquired antibodies are important in human immunity to malaria, but key
targets remain largely unknown. Plasmodium falciparum reticulocyte-binding-homologue-4 …
targets remain largely unknown. Plasmodium falciparum reticulocyte-binding-homologue-4 …
Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing …
Plasmodium falciparum reticulocyte binding-like homologous protein 5 (PfRH5) is an
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
[HTML][HTML] The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
AD Douglas, AR Williams, JJ Illingworth… - Nature …, 2011 - nature.com
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are
mostly focused on well-studied merozoite antigens that induce immune responses after …
mostly focused on well-studied merozoite antigens that induce immune responses after …
Mechanisms of naturally acquired immunity to P. falciparum and approaches to identify merozoite antigen targets
J Healer, CY Chiu, DS Hansen - Parasitology, 2018 - cambridge.org
Malaria is one the most serious infectious diseases with over 200 million clinical cases
annually. Most cases of the severe disease are caused by Plasmodium falciparum. The …
annually. Most cases of the severe disease are caused by Plasmodium falciparum. The …