The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells
E Vickridge, CCF Faraco, PS Tehrani… - NAR …, 2022 - academic.oup.com
We identified the BCL11A protein in a proximity-dependent biotinylation screen performed
with the DNA glycosylase NTHL1. In vitro, DNA repair assays demonstrate that both BCL11A …
with the DNA glycosylase NTHL1. In vitro, DNA repair assays demonstrate that both BCL11A …
The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene
E Vickridge, CCF Faraco, F Lo, H Rahimian… - Nucleic acids …, 2024 - academic.oup.com
Genetic studies in mice and human cancers established BCL11B as a haploinsufficient
tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers …
tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers …
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF–p53 signaling
A Shvarts, TR Brummelkamp, F Scheeren… - Genes & …, 2002 - genesdev.cshlp.org
Senescence limits the proliferative capacity of primary cells in culture. We describe here a
genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA …
genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA …
BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response
H Zhao, M Zhu, G Dou, H Zhao, B Zhu, J Li, J Liao… - Cell cycle, 2014 - Taylor & Francis
Timely and proper cellular response to DNA damage is essential for maintenance of
genome stability and integrity. B-cell lymphoma/leukemia 10 (BCL10) facilitates …
genome stability and integrity. B-cell lymphoma/leukemia 10 (BCL10) facilitates …
[HTML][HTML] Suppression of Bcl3 disrupts viability of breast cancer cells through both p53-dependent and p53-independent mechanisms via loss of NF-κB signalling
DJ Turnham, H Smith, RWE Clarkson - Biomedicines, 2024 - mdpi.com
The NF-κB co-factor Bcl3 is a proto-oncogene that promotes breast cancer proliferation,
metastasis and therapeutic resistance, yet its role in breast cancer cell survival is unclear …
metastasis and therapeutic resistance, yet its role in breast cancer cell survival is unclear …
BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair
IH Ismail, A Dronyk, X Hu, MJ Hendzel, AR Shaw - Cell cycle, 2016 - Taylor & Francis
Recent studies have found BCL10 can localize to the nucleus and that this is linked to tumor
aggression and poorer prognosis. These studies suggest that BCL10 localization plays a …
aggression and poorer prognosis. These studies suggest that BCL10 localization plays a …
BCL7C suppresses ovarian cancer growth by inactivating mutant p53
C Huang, Q Hao, G Shi, X Zhou… - Journal of Molecular Cell …, 2021 - academic.oup.com
B-cell CLL/lymphoma 7 protein family member C (BCL7C) located at chromosome 16p11. 2
shares partial sequence homology with the other two family members, BCL7A and BCL7B …
shares partial sequence homology with the other two family members, BCL7A and BCL7B …
[HTML][HTML] BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells
WT Khaled, S Choon Lee, J Stingl, X Chen… - Nature …, 2015 - nature.com
Triple-negative breast cancer (TNBC) has poor prognostic outcome compared with other
types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology …
types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology …
Bcl-2 promotes premature senescence induced by oncogenic Ras
B Tombor, K Rundell, ZN Oltvai - Biochemical and biophysical research …, 2003 - Elsevier
The expression of the apoptosis inhibitory protein, Bcl-2, is increased in naturally senescing
human fibroblasts and upon induction of their senescence-like growth arrest by oxidative …
human fibroblasts and upon induction of their senescence-like growth arrest by oxidative …
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis
E Schmitt, C Paquet, M Beauchemin… - Journal of Zhejiang …, 2007 - Springer
Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation,
cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly …
cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly …