Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

Innate and adaptive defense mechanisms protect the respiratory system from attack by
microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the …

Taste receptors on the tongue communicate information to the brain about the nutrient
content or potential toxicity of ingested foods. However, recent research has now shown that …

In the upper respiratory epithelium, bitter and sweet taste receptors present in solitary
chemosensory cells influence antimicrobial innate immune defense responses. Whereas …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …

Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …

Constant exposure of the airways to inhaled pathogens requires efficient early immune
responses protecting against infections. How bacteria on the epithelial surface are detected …

Background Maintaining a clean upper respiratory tract requires efficient detection of
pathogenic bacteria so that the airway mucosa can mount proper defenses to neutralize and …

The upper respiratory tract is continually assaulted with harmful dusts and xenobiotics
carried on the incoming airstream. Detection of such irritants by the trigeminal nerve evokes …