Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

Allelic differences between the two homologous chromosomes can affect the propensity of
inheritance in humans; however, the extent of such differences in the human genome has …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …

The ENCODE Project has generated a wealth of experimental information mapping diverse
chromatin properties in several human cell lines. Although each such data track is …

A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Physical interaction of regulatory elements in three-dimensional space poses a challenge
for studies of disease because non-coding risk variants may be great distances from the …

Identification of functional, noncoding elements that regulate transcription in the context of
complex genomes is a major goal of modern biology. Localization of functionality to specific …