Identification of tumor-antigen signatures and immune subtypes for messenger RNA vaccine selection in advanced clear cell renal cell carcinoma

Z Xu, Y Wu, X Chen, B Jin - Surgery, 2024 - Elsevier
Background Advanced clear cell renal cell carcinoma still lacks reliable diagnostic and
prognostic biomarkers. Recently, tumor vaccines targeting specific molecules have been …

Tumor antigens and immune subtypes guided mRNA vaccine development for kidney renal clear cell carcinoma

H Xu, X Zheng, S Zhang, X Yi, T Zhang, Q Wei, H Li… - Molecular cancer, 2021 - Springer
Current treatment strategy for kidney renal clear cell carcinoma (KIRC) is limited. Tumor-
associated antigens, especially neoantigen-based personalized mRNA vaccines represent …

[HTML][HTML] Identification of neoantigens and immunological subtypes in clear cell renal cell carcinoma for mRNA vaccine development and patient selection

D Zhu, J Yang, M Zhang, Z Han, M Shao, Q Fan… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Clear cell renal cell carcinoma (ccRCC) is a common urological malignancy with diverse
histological types. This study aimed to detect neoantigens in ccRCC to develop mRNA …

Identification of Five Tumor Antigens for Development and Two Immune Subtypes for Personalized Medicine of mRNA Vaccines in Papillary Renal Cell Carcinoma

J Hu, Z Yuan, Y Jiang, Z Mo - Journal of Personalized Medicine, 2023 - mdpi.com
Increasing evidence has revealed the promise of mRNA-type cancer vaccines as a new
direction for cancer immune treatment in several solid tumors, however, its application in …

Novel prognosis and therapeutic response model of immune-related lncRNA pairs in clear cell renal cell carcinoma

G Wang, P Liu, J Li, K Jin, X Zheng, L Xie - Vaccines, 2022 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal carcinoma. It is
particularly important to accurately judge the prognosis of patients. Since most tumor …

A united risk model of 11 immune‑related gene pairs and clinical stage for prediction of overall survival in clear cell renal cell carcinoma patients

Z Tao, E Zhang, L Li, J Zheng, Y Zhao, X Chen - Bioengineered, 2021 - Taylor & Francis
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer.
Currently, we lack effective risk models for the prognosis of ccRCC patients. Given the …

A 14 immune-related gene signature predicts clinical outcomes of kidney renal clear cell carcinoma

Y Zou, C Hu - PeerJ, 2020 - peerj.com
Kidney renal clear cell carcinoma (KIRC) is the leading cause of kidney cancer-related
deaths. Currently, there are no studies in tumor immunology investigating the use of …

A predictive signature based on enhancer RNA associates with immune infiltration and aids treatment decision in clear cell renal cell carcinoma

Q Li, X Xiao, B Chen, G Song, K Zeng, B Li… - Frontiers in …, 2022 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is a prevalent urinary malignancy. Despite the
recent development of better diagnostic tools and therapy, the five-year survival rate for …

External validation of the prognostic value of an immune-associated gene panel for clear cell renal cell carcinomas

Z Xie, L Wu, S Hua, Y Zhang, F Shi, M Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrates, and many of them
respond to immunotherapy with checkpoint inhibitors including anti-PD-L1 or anti-PD1 …

Development of an Individualized Immune Prognostic Signature for Clear Cell Renal Cell Carcinoma through the Identification of Differential Immune Genes

J Wang, C Tang, X Liu - Journal of Oncology, 2021 - Wiley Online Library
Increasing evidence has shown that tumor microenvironments are an important feature in
clear cell renal cell carcinoma (ccRCC) carcinogenesis and therapeutic efficacy. In this …