Strategies for the synthesis of indole diketopiperazine alkaloids (indole DKPs) have been
described and involve three analogs of indole DKPs. The antimicrobial activity and structure …

Nitrogen-containing heterocycles have shown pharmacological properties against various
diseases. Herein, in our study, flavoHB enzyme is a highly promising well-validated target …

Herein, we describe the successful design and synthesis of seventeen new 1, 4-diazinanes,
compounds commonly known as piperazines. This group of piperazine derivatives (3a-q) …

FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is critically important to the initiation
of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative …

Nitroimidazoles and their derivatives have drawn continuing interest over the years because
of their varied biological activities, recently found application in drug development for …

The enzyme FabH plays a critical role in the initial step of fatty acid biosynthesis, which is
vital for the survival of bacteria. As a result, FabH has emerged as an appealing target for the …

A new series of pyrrolyl phenoxy derivatives bearing alkoxy linker were synthesized and
evaluated for anti-tubercular activity (anti-TB) against Mycobacterium tuberculosis …

Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …

In this research, previously and newly synthesized 5-amino-2-(4-substitutedphenyl/benzyl)
benzoxazoles (3a–3l) and 2-substituted-5-(4-nitro/aminophenylsulfonamido) benzoxazoles …

Because of the growing bacterial resistance to antibiotics, the discovery of new antibiotics is
critical. The search for new antimicrobial drugs that are effective in treating new and existing …