Advances and challenges in hemophilic arthropathy

T Wyseure, LO Mosnier, A von Drygalski - Seminars in hematology, 2016 - Elsevier
Hemophilic arthropathy is a form of joint disease that develops secondary to joint bleeding
and presents with synovial hypertrophy, cartilage and bony destruction. The arthropathy can …

Asymptomatic joint bleeding and joint health in hemophilia: a review of variables, methods, and biomarkers

R Gooding, J Thachil, J Alamelu, J Motwani… - Journal of Blood …, 2021 - Taylor & Francis
Joint health is a key contributor to quality of life in patients with hemophilia. However,
variables that impact long-term joint outcomes have not been comprehensively defined. A …

Pathogenesis of hemophilic arthropathy

WK Hoots - Seminars in hematology, 2006 - Elsevier
Intra-articular bleeding is the most common clinical manifestation of hemophilia, and can
adversely affect joints and lead to arthropathy. Affected joints are associated with changes to …

Pathophysiology of hemophilic arthropathy and potential targets for therapy

AE Pulles, SC Mastbergen, REG Schutgens… - Pharmacological …, 2017 - Elsevier
Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Understanding haemophilic arthropathy: an exploration of current open issues

NWD Jansen, G Roosendaal… - British journal of …, 2008 - Wiley Online Library
Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in
patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic …

Joint disease in haemophilia: pathophysiology, pain and imaging

LFD Van Vulpen, K Holstein, C Martinoli - Haemophilia, 2018 - Wiley Online Library
Haemarthroses cause major morbidity in patients with haemophilia. Blood has devastating
effects on all joint components, resulting in synovitis, osteochondral degeneration and …

Assessment of hemophilic arthropathy by ultrasound: where do we stand?

MND Di Minno, P Ambrosino… - … in Thrombosis and …, 2016 - thieme-connect.com
Joint hemorrhages represent the most common type of bleeding episode in persons with
hemophilia, and recurrent hemarthrosis triggers chronic arthropathy, which is the most …

Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity

CP Blobel, C Haxaire, GD Kalliolias… - … in Thrombosis and …, 2015 - thieme-connect.com
Hemophilia A is an X-linked bleeding disorder that can be largely controlled by treatment
with recombinant factor VIII. However, this treatment is only partially effective in preventing …

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

AS Doria - Haemophilia, 2010 - Wiley Online Library
In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratory‐
based, imaging has become an important tool for the evaluation of complications, diagnostic …

Pathophysiology of hemophilic arthropathy

D Melchiorre, M Manetti, M Matucci-Cerinic - Journal of clinical medicine, 2017 - mdpi.com
Spontaneous joint bleeding and repeated hemarthroses lead to hemophilic arthropathy—a
debilitating disease with a significant negative impact on mobility and quality of life. Iron …