[HTML][HTML] Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
A Fekete, Y Nakamura, YM Yang, S Herlitze… - Nature …, 2019 - nature.com
Synaptic heterogeneity is widely observed but its underpinnings remain elusive. We
addressed this issue using mature calyx of Held synapses whose numbers of bouton-like …
addressed this issue using mature calyx of Held synapses whose numbers of bouton-like …
[HTML][HTML] Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function
The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and
synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct …
synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct …
[HTML][HTML] Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses
L Guillaud, D Dimitrov, T Takahashi - Elife, 2017 - elifesciences.org
Transport of synaptic vesicles (SVs) in nerve terminals is thought to play essential roles in
maintenance of neurotransmission. To identify factors modulating SV movements, we …
maintenance of neurotransmission. To identify factors modulating SV movements, we …
[HTML][HTML] Intrinsic variability in Pv, RRP size, Ca2+ channel repertoire, and presynaptic potentiation in individual synaptic boutons
The strength of individual synaptic contacts is considered a key modulator of information
flow across circuits. Presynaptically the strength can be parsed into two key parameters: the …
flow across circuits. Presynaptically the strength can be parsed into two key parameters: the …
[HTML][HTML] Spatially non-overlapping Ca2+ signals drive distinct forms of neurotransmission
Summary Calcium (Ca 2+) signaling is tightly regulated within a presynaptic bouton. Here,
we visualize Ca 2+ signals within hippocampal presynaptic boutons using GCaMP8s tagged …
we visualize Ca 2+ signals within hippocampal presynaptic boutons using GCaMP8s tagged …
[HTML][HTML] Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity
AT Medeiros, SJ Gratz, A Delgado, JT Ritt… - eLife, 2024 - elifesciences.org
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …
Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity.
AT Medeiros, SJ Gratz, A Delgado, JT Ritt… - Elife, 2024 - search.ebscohost.com
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …
[HTML][HTML] Septins regulate developmental switching from microdomain to nanodomain coupling of Ca2+ influx to neurotransmitter release at a central synapse
YM Yang, MJ Fedchyshyn, G Grande, J Aitoubah… - Neuron, 2010 - cell.com
Neurotransmitter release depends critically on close spatial coupling of Ca 2+ entry to
synaptic vesicles at the nerve terminal; however, the molecular substrates determining their …
synaptic vesicles at the nerve terminal; however, the molecular substrates determining their …
[HTML][HTML] Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons
The transformation of synaptic input into action potential output is a fundamental single-cell
computation resulting from the complex interaction of distinct cellular morphology and the …
computation resulting from the complex interaction of distinct cellular morphology and the …
Target cell type-dependent differences in Ca2+ channel function underlie distinct release probabilities at hippocampal glutamatergic terminals
T Éltes, T Kirizs, Z Nusser, N Holderith - Journal of Neuroscience, 2017 - Soc Neuroscience
Target cell type-dependent differences in presynaptic release probability (Pr) and short-term
plasticity are intriguing features of cortical microcircuits that increase the computational …
plasticity are intriguing features of cortical microcircuits that increase the computational …