The hemochromatosis gene HFE was discovered in 1996, more than a century after clinical
and pathologic manifestations of hemochromatosis were reported. Linked to the major …

Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized
by increased iron absorption and progressive iron storage that results in damage to major …

Hereditary hemochromatosis (HH) is an autosomal recessive disease characterized by iron
accumulation in several organs, followed by organ damage and failure. The C282Y mutation …

Background: Hereditary hemochromatosis is an inherited disorder of iron metabolism that is
characterized by excessive iron deposition in major organs of the body. Chronic increased …

The iron overload disorder, hereditary hemochromatosis, is one of the most common genetic
diseases of individuals of Northern European descent. The disorder is characterized by the …

The puzzling linkage between genetic hemochromatosis and histocompatibility loci became
even more so when the gene involved, HFE, was identified. Indeed, within the well defined …

Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by
mutation in HFE, a gene encoding an MHC class I-like protein. Clinical studies demonstrate …

Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron
metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron …

Hereditary hemochromatosis (HH) comprises several inherited disorders of iron
homeostasis characterized by increased gastrointestinal iron absorption and resultant tissue …

The HFE locus encodes an HLA class-I-type protein important in iron regulation and
segregates replacement mutations that give rise to the most common form of genetic …