Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

VS Tagliabracci, JL Engel, SE Wiley… - Proceedings of the …, 2014 - National Acad Sciences
The family with sequence similarity 20, member C (Fam20C) has recently been identified as
the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs …

Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence

JM Revest, L DeMoerlooze, C Dickson - Journal of Biological Chemistry, 2000 - ASBMB
Fibroblast growth factors are a family of intercellular signaling molecules with multiple and
varied roles in animal development. Most are exported from cells by means of a classical …

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

EY Zhen, Z Jin, BL Ackermann, MK Thomas… - Biochemical …, 2016 - portlandpress.com
Fibroblast growth factor 21 (FGF21), a hormone implicated in the regulation of glucose
homoeostasis, insulin sensitivity, lipid metabolism and body weight, is considered to be a …

Upstream regulators of fibroblast growth factor 23

DMA Ratsma, MC Zillikens… - Frontiers in …, 2021 - frontiersin.org
Fibroblast growth factor 23 (FGF23) has been described as an important regulator of mineral
homeostasis, but has lately also been linked to iron deficiency, inflammation, and …

FGF23 signalling and physiology

BB Ho, C Bergwitz - Journal of molecular endocrinology, 2021 - jme.bioscientifica.com
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …

Biosynthetic FGF-2 is targeted to non-lipid raft microdomains following translocation to the extracellular surface of CHO cells

A Engling, R Backhaus, C Stegmayer… - Journal of cell …, 2002 - journals.biologists.com
Basic fibroblast growth factor (FGF-2) is a secretory protein that lacks a signal peptide.
Consistently, FGF-2 has been shown to be secreted by an ER-Golgi-independent …

The regulation of FGF23 under physiological and pathophysiological conditions

S Rausch, M Föller - Pflügers Archiv-European Journal of Physiology, 2022 - Springer
Abstract Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates
phosphate homeostasis in the kidney along with active vitamin D (1, 25 (OH) 2D3) and …

Circulating FGF21 levels in human health and metabolic disease

M Keuper, HU Häring, H Staiger - Experimental and Clinical …, 2020 - thieme-connect.com
Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as
a hepatokine. This hormone circulates to its target tissues (eg, brain, adipose tissue), which …

[HTML][HTML] Endocytosis controls spreading and effective signaling range of Fgf8 protein

S Scholpp, M Brand - Current Biology, 2004 - cell.com
Secreted signaling molecules released from a restricted source are of great importance
during embryonic development because they elicit induction, proliferation, differentiation …

Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice

X Wang, S Wang, C Li, T Gao, Y Liu, A Rangiani… - PLoS …, 2012 - journals.plos.org
Fam ily with sequence similarity 20,-member C (FAM20C) is highly expressed in the
mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations …