Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Stroke is a major cause of morbidity and mortality, and activation of the immune system can
impact on stroke outcome. Although the majority of research has focused on the role of the …

Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

The immune response to acute cerebral ischemia is a major factor in stroke pathobiology
and outcome. While the immune response starts locally in occluded and hypoperfused …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Acute ischemic stroke is the third leading cause of death in industrialized countries and the
most frequent cause of permanent disability in adults worldwide. Despite advances in the …

Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each
year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke …