An updated overview of experimental and computational approaches to identify non-canonical DNA/RNA structures with emphasis on G-quadruplexes and R-loops
X Shi, H Teng, Z Sun - Briefings in Bioinformatics, 2022 - academic.oup.com
Multiple types of non-canonical nucleic acid structures play essential roles in DNA
recombination and replication, transcription, and genomic instability and have been …
recombination and replication, transcription, and genomic instability and have been …
Structure, location and interactions of G‐quadruplexes
JL Huppert - The FEBS journal, 2010 - Wiley Online Library
Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of
increasing interest recently. Experimental and computational techniques have been used to …
increasing interest recently. Experimental and computational techniques have been used to …
A machine learning perspective on DNA and RNA G-quadruplexes
F Rossi, A Paiardini - Current Bioinformatics, 2022 - ingentaconnect.com
G-quadruplexes (G4s) are particular structures found in guanine-rich DNA and RNA
sequences that exhibit a wide diversity of three-dimensional conformations and exert key …
sequences that exhibit a wide diversity of three-dimensional conformations and exert key …
Strategy for modeling higher-order G-quadruplex structures recalcitrant to NMR determination
TM Sabo, JO Trent, JB Chaires, RC Monsen - Methods, 2024 - Elsevier
Guanine-rich nucleic acids can form intramolecularly folded four-stranded structures known
as G-quadruplexes (G4s). Traditionally, G4 research has focused on short, highly modified …
as G-quadruplexes (G4s). Traditionally, G4 research has focused on short, highly modified …
The application of DNA and RNA G-quadruplexes to therapeutic medicines
GW Collie, GN Parkinson - Chemical Society Reviews, 2011 - pubs.rsc.org
The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …
QPARSE: searching for long-looped or multimeric G-quadruplexes potentially distinctive and druggable
Motivation G-quadruplexes (G4s) are non-canonical nucleic acid conformations that are
widespread in all kingdoms of life and are emerging as important regulators both in RNA …
widespread in all kingdoms of life and are emerging as important regulators both in RNA …
G-quadruplexes in mRNA: A key structure for biological function
T Kamura, Y Katsuda, Y Kitamura, T Ihara - Biochemical and biophysical …, 2020 - Elsevier
The last several years have seen exciting advances in the understanding of the structure
and function of higher-order structures of RNA. Expression levels of some specific genes …
and function of higher-order structures of RNA. Expression levels of some specific genes …
[HTML][HTML] Special Issue “Bioinformatics of Unusual DNA and RNA Structures”
Nucleic acids are not only static carriers of genetic information but also play vital roles in
controlling cellular lifecycles through their fascinating structural diversity. Gone are the days …
controlling cellular lifecycles through their fascinating structural diversity. Gone are the days …
The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology
Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other
nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA …
nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA …
Characterization of DNA G-quadruplex topologies with NMR chemical shifts
RK Reddy Sannapureddi, MK Mohanty… - The Journal of …, 2020 - ACS Publications
G-quadruplexes are nucleic acid motifs formed by stacking of guanosine-tetrad
pseudoplanes. They perform varied biological roles, and their distinctive structural features …
pseudoplanes. They perform varied biological roles, and their distinctive structural features …