An updated overview of experimental and computational approaches to identify non-canonical DNA/RNA structures with emphasis on G-quadruplexes and R-loops

X Shi, H Teng, Z Sun - Briefings in Bioinformatics, 2022 - academic.oup.com
Multiple types of non-canonical nucleic acid structures play essential roles in DNA
recombination and replication, transcription, and genomic instability and have been …

Structure, location and interactions of G‐quadruplexes

JL Huppert - The FEBS journal, 2010 - Wiley Online Library
Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of
increasing interest recently. Experimental and computational techniques have been used to …

A machine learning perspective on DNA and RNA G-quadruplexes

F Rossi, A Paiardini - Current Bioinformatics, 2022 - ingentaconnect.com
G-quadruplexes (G4s) are particular structures found in guanine-rich DNA and RNA
sequences that exhibit a wide diversity of three-dimensional conformations and exert key …

Strategy for modeling higher-order G-quadruplex structures recalcitrant to NMR determination

TM Sabo, JO Trent, JB Chaires, RC Monsen - Methods, 2024 - Elsevier
Guanine-rich nucleic acids can form intramolecularly folded four-stranded structures known
as G-quadruplexes (G4s). Traditionally, G4 research has focused on short, highly modified …

The application of DNA and RNA G-quadruplexes to therapeutic medicines

GW Collie, GN Parkinson - Chemical Society Reviews, 2011 - pubs.rsc.org
The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

QPARSE: searching for long-looped or multimeric G-quadruplexes potentially distinctive and druggable

M Berselli, E Lavezzo, S Toppo - Bioinformatics, 2020 - academic.oup.com
Motivation G-quadruplexes (G4s) are non-canonical nucleic acid conformations that are
widespread in all kingdoms of life and are emerging as important regulators both in RNA …

G-quadruplexes in mRNA: A key structure for biological function

T Kamura, Y Katsuda, Y Kitamura, T Ihara - Biochemical and biophysical …, 2020 - Elsevier
The last several years have seen exciting advances in the understanding of the structure
and function of higher-order structures of RNA. Expression levels of some specific genes …

[HTML][HTML] Special Issue “Bioinformatics of Unusual DNA and RNA Structures”

M Bartas, V Brázda, P Pečinka - International Journal of Molecular …, 2024 - mdpi.com
Nucleic acids are not only static carriers of genetic information but also play vital roles in
controlling cellular lifecycles through their fascinating structural diversity. Gone are the days …

The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology

J Chen, M Cheng, GF Salgado… - Nucleic Acids …, 2021 - academic.oup.com
Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other
nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA …

Characterization of DNA G-quadruplex topologies with NMR chemical shifts

RK Reddy Sannapureddi, MK Mohanty… - The Journal of …, 2020 - ACS Publications
G-quadruplexes are nucleic acid motifs formed by stacking of guanosine-tetrad
pseudoplanes. They perform varied biological roles, and their distinctive structural features …