A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …
are emerging as treatment options. This study sought to identify the most prevalent …
Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for …
Background. Gastric cancer (GC) is a major global cancer burden and the second most
common cause of global cancer-related deaths. The addition of anti-ERBB2 (HER2) …
common cause of global cancer-related deaths. The addition of anti-ERBB2 (HER2) …
[HTML][HTML] Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer
Y Kuboki, S Yamashita, T Niwa, T Ushijima… - Annals of …, 2016 - Elsevier
Background In advanced gastric cancer (AGC), most clinical trials are designed on the basis
of protein expression or gene amplification of specific genes. Recently, next-generation …
of protein expression or gene amplification of specific genes. Recently, next-generation …
[HTML][HTML] An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa
H Yamamoto, Y Watanabe, T Maehata… - World journal of …, 2014 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most common malignancies and remains the second
leading cause of cancer-related death worldwide. There is an increasing understanding of …
leading cause of cancer-related death worldwide. There is an increasing understanding of …
Actionable gene-based classification toward precision medicine in gastric cancer
H Ichikawa, M Nagahashi, Y Shimada, T Hanyu… - Genome Medicine, 2017 - Springer
Background Intertumoral heterogeneity represents a significant hurdle to identifying
optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC …
optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC …
Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing
H Cai, C Jing, X Chang, D Ding, T Han, J Yang… - Journal of translational …, 2019 - Springer
Background Gastric cancer (GC) is a leading cause of cancer deaths, and an increased
number of GC patients adopt to next-generation sequencing (NGS) to identify tumor …
number of GC patients adopt to next-generation sequencing (NGS) to identify tumor …
Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis
AM Dulak, SE Schumacher, J Van Lieshout, Y Imamura… - Cancer research, 2012 - AACR
A more detailed understanding of the somatic genetic events that drive gastrointestinal
adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high …
adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high …
[HTML][HTML] Gastric cancer genomics: advances and future directions
BW Katona, AK Rustgi - Cellular and molecular gastroenterology and …, 2017 - Elsevier
Advancement in the field of cancer genomics is revolutionizing the molecular
characterization of a wide variety of different cancers. Recent application of large-scale, next …
characterization of a wide variety of different cancers. Recent application of large-scale, next …
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
K Wang, ST Yuen, J Xu, SP Lee, HHN Yan, ST Shi… - Nature …, 2014 - nature.com
Gastric cancer is a heterogeneous disease with diverse molecular and histological
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …
HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma
Background: Gastric cancer (GC) is a leading cause of cancer deaths worldwide. Since the
approval of trastuzumab, targeted therapies are emerging as promising treatment options for …
approval of trastuzumab, targeted therapies are emerging as promising treatment options for …
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