Nucleation, stabilization, and disassembly of branched actin networks
AM Gautreau, FE Fregoso, G Simanov… - Trends in cell …, 2022 - cell.com
Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability
ED Goley, A Rammohan… - Proceedings of the …, 2010 - National Acad Sciences
The Arp2/3 complex polymerizes new actin filaments from the sides of existing filaments,
forming Y-branched networks that are critical for actin-mediated force generation. Binding of …
forming Y-branched networks that are critical for actin-mediated force generation. Binding of …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
B Ding, HY Narvaez-Ortiz, Y Singh… - Proceedings of the …, 2022 - National Acad Sciences
Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …
Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions
Actin branch junctions are conserved cytoskeletal elements critical for the generation of
protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch …
protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch …
From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly
Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …
Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction
The actin-related protein (Arp) 2/3 complex nucleates branched actin filament networks
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …
MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes
C Galloni, D Carra, JVG Abella, S Kjær… - Journal of Cell …, 2021 - rupress.org
The mechanisms regulating the disassembly of branched actin networks formed by the
Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on …
Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on …
Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism
A Zimmet, T Van Eeuwen, M Boczkowska… - Science …, 2020 - science.org
Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell
motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3) …
motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3) …
ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning
Regulation of the Arp2/3 complex is required for productive nucleation of branched actin
networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the …
networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the …