Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining,
serves as the benchmark for disease diagnosis and comprehensive clinical assessment of …

Brain tumor surgery involves a delicate balance between maximizing the extent of tumor
resection while minimizing damage to healthy brain tissue that is vital for neurological …

Using a deep neural network, we demonstrate a digital staining technique, which we term
PhaseStain, to transform the quantitative phase images (QPI) of label-free tissue sections …

Quantitative phase microscopy (QPM) is a label-free technique that enables monitoring of
morphological changes at the subcellular level. The performance of the QPM system in …

Optical quantitative phase imaging (QPI) is a frequently used technique to recover biological
cells with high contrast in biology and life science for cell detection and analysis. However …

Histological hematoxylin and eosin–stained (H&E) tissue sections are used as the gold
standard for pathologic detection of cancer, tumor margin detection, and disease diagnosis …

Highlights•Label-free QPI can overcome the specificity gap over fluorescence microscopy
(FM).•The specificity in QPI can be achieved from 2D phase maps or 3D RI tomograms.•2D …

Utilizing the refractive index as the endogenous contrast agent to noninvasively study
transparent cells is a working principle of emerging quantitative phase imaging (QPI). In this …

Quantitative oblique back-illumination microscopy (qOBM) is an emerging label-free optical
imaging technology that enables 3D, tomographic quantitative phase imaging (QPI) with epi …

Slide-free digital pathology techniques, including nondestructive 3D microscopy, are gaining
interest as alternatives to traditional slide-based histology. In order to facilitate clinical …