Conditioning, the recruitment of endogenous cytoprotective pathways that protect the
myocardium against injurious ischaemia/reperfusion injury, has developed into a range of …

Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the
knowledge about the mechanisms and signaling pathways involved in these processes has …

Following the initiation of an ischemic insult, reperfusion injury (RI) can result in numerous
deleterious cardiac effects, including cardiomyocyte death. Experimental data have …

Ischemic heart failure is one of the leading causes of death in the western countries and it is
a critical issue to overcome ischemic heart diseases for the human health care worldwide …

INTRODUCTION Acute ST-elevation myocardial infarction (STEMI) is characterised by
unpredictable epicardial artery occlusion. The myocardium supplied by the vessel is …

The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Coronary heart disease (CHD) is the leading cause of death worldwide. The development of
novel treatment strategies for protecting the myocardium against the detrimental effects of …

Coronary heart disease (CHD) is the leading cause of death world-wide. Its major
pathophysiological manifestation is acute myocardial ischaemia–reperfusion injury …

Current cellular models of ischemic preconditioning (IPC) rely on inducing preconditioning
in vitro and may not accurately represent complex pathways triggered by IPC in the intact …

The aim of pharmacological conditioning is to protect the heart against myocardial ischemia-
reperfusion (I/R) injury and its consequences. There is extensive literature that reports a …