Bone remodeling is a continuous physiological process that requires constant generation of
new osteoblasts from mesenchymal stem cells (MSCs). Differentiation of MSCs to osteoblast …

Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species
(ROS) play an important role in physiological intracellular signalling by triggering …

Accumulation of reactive oxygen species (ROS) induced by oxidative stress (OS) affects cell
survival, cell function and even results in cell death. As a major transcription factor of …

Decline of antioxidant defense after estrogen deficiency leads to oxidative damage in bone
marrow-derived mesenchymal stem cells (BMMSCs), resulting a defect of bone formation in …

Bone remodeling is regulated by local factors that regulate bone-forming osteoblasts and
boneresorbing osteoclasts, in addition to hormonal activity. Recent studies have shown that …

Mesenchymal stem cells (MSCs) are a promising regenerative medicine. The roles of
miRNAs in osteogenic differentiation of bone marrow MSCs (BM-MSCs) remained less …

Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast
numbers and increased levels of oxidative stress within osteoblasts. Since transcription …

Several mechanisms contribute to the decline of all physiologic functions during aging. As a
consequence, disease incidence increases with age. Central to this multifactorial process is …

Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …