Asthma: pathogenesis and novel drugs for treatment

JT Olin, ME Wechsler - Bmj, 2014 - bmj.com
Asthma affects almost 20 million people in the United States and more than 300 million
people worldwide. Of these, 10-15% have severe asthma, which is refractory to commonly …

New therapies for asthma: is there any progress?

PJ Barnes - Trends in pharmacological sciences, 2010 - cell.com
Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β 2-agonists
is highly effective, safe and relatively inexpensive, but for many patients, their disease …

Diagnosis and management of asthma in children

A Bush, L Fleming - Bmj, 2015 - bmj.com
Diagnosis and management of asthma in children | The BMJ Skip to main content Intended for
healthcare professionals Access provided by Google Indexer Subscribe My Account My email …

New targets for drug development in asthma

IM Adcock, G Caramori, KF Chung - The Lancet, 2008 - thelancet.com
Asthma is a chronic inflammatory disease that affects about 300 million people worldwide, a
total that is expected to rise to about 400 million over the next 15–20 years. Most asthmatic …

New drugs for asthma

PJ Barnes - Nature reviews Drug discovery, 2004 - nature.com
Asthma is a major and increasing global health problem and, despite major advances in
therapy, many patients' symptoms are not adequately controlled. Treatment with …

Childhood asthma: diagnosis and treatment

WM van Aalderen - Scientifica, 2012 - Wiley Online Library
Many children suffer from recurrent coughing, wheezing and chest tightness. In preschool
children one third of all children have these symptoms before the age of six, but only 40% of …

Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma

MC Peters, SE Wenzel - The Lancet, 2020 - thelancet.com
Asthma is a disease of reversible airflow obstruction characterised clinically by wheezing,
shortness of breath, and coughing. Increases in airway type 2 cytokine activity, including …

Drugs for asthma

PJ Barnes - British journal of pharmacology, 2006 - Wiley Online Library
Current drug therapy for asthma is highly effective and has evolved from naturally occurring
substances through logical pharmaceutical developments. Pharmacology has played a …

Factors in childhood as predictors of asthma in adult life

MA Jenkins, JL Hopper, G Bowes, JB Carlin… - Bmj, 1994 - bmj.com
Objective: To determine which factors measured in childhood predict asthma in adult life.
Design: Prospective study over 25 years of a birth cohort initially studied at the age of 7 …

Asthma in children

GL Larsen - New England Journal of Medicine, 1992 - Mass Medical Soc
DURING the past two decades, important insights have been gained into the pathogenesis
of asthma. Despite our greater knowledge, national statistics reveal increasing morbidity and …