Genetic alteration and their significance on clinical events in small cell lung cancer

S Jiao, X Zhang, D Wang, H Fu… - Cancer Management and …, 2023 - Taylor & Francis
Introduction Small cell lung cancer (SCLC), an aggressive subtype of lung cancer
characterized by the development of neuroendocrine tumors, is prone to distant metastasis …

Comprehensive genomic analysis of small cell lung cancer in Asian patients.

S Umemura, K Goto, S Mimaki, G Ishii, H Ohmatsu… - 2013 - ascopubs.org
7512 Background: Small cell lung cancer (SCLC) is an aggressive disease with poor
prognosis. There is an urgent need for detecting well-defined therapeutic targets, however …

[HTML][HTML] Molecular genetic profiling of small cell lung carcinoma in a Chinese cohort

Z Wang, Z Jiang, H Lu - Translational Cancer Research, 2019 - ncbi.nlm.nih.gov
Background Small cell lung cancer (SCLC) has unique biology and chromosomal
modifications; however, only a few studies have investigated the molecular map of SCLC …

Genomic features of Chinese small cell lung cancer

J Liu, Z Zhao, S Wei, B Li, Z Zhao - BMC Medical Genomics, 2022 - Springer
Background Small cell lung cancer (SCLC) is an aggressive disease with poor survival.
Although molecular and clinical characteristics have been established for SCLC in western …

Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS‐Based Targeted Resequencing Gene Panel and Relation with Clinical Features

W Jin, Z Lei, S Xu, Z Fachen, Z Yixiang… - BioMed research …, 2021 - Wiley Online Library
Background. Small cell lung cancer (SCLC) is an aggressive and invasive malignancy that
presents at advanced clinical stage with no more effective treatments. Development of a …

Molecular subtyping of small‐cell lung cancer based on mutational signatures with different genomic features and therapeutic strategies

H Wang, S Wu, Z Li, C Zhang, X Shang, C Zhao… - Cancer …, 2023 - Wiley Online Library
Small‐cell lung cancer (SCLC) is an exceptionally lethal malignancy characterized by
extremely high alteration rates and tumor heterogeneity, which limits therapeutic options. In …

Evolution of small cell lung cancer tumor mutation: from molecular mechanisms to novel viewpoints

X Guan, G Bao, J Liang, Y Yao, Y Xiang… - Seminars in Cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is a clinically common malignant tumor originating from the
lung neuroendocrine stem cells, which has a poor prognosis and accounts for approximately …

Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential

J Hu, Y Wang, Y Zhang, Y Yu, H Chen, K Liu… - Cancer …, 2019 - Wiley Online Library
Background Small cell lung cancer (SCLC) is one of the deadliest malignancies and
accounts for nearly 15% of lung cancers. Previous study had revealed the genomic …

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis

H Udagawa, S Umemura, I Murakami, S Mimaki… - Lung Cancer, 2018 - Elsevier
Objectives Comprehensive genomic analysis of small-cell lung cancer (SCLC) revealed
various genetic alterations. However, obtaining suitable samples for genetic analysis is …

[HTML][HTML] Distinct patterns of somatic genomic alterations and mutational signatures in central and peripheral-type small-cell lung cancer

L Wang, J Wang, J Hu, L Song, J Ni, Y He… - … Lung Cancer Research, 2021 - ncbi.nlm.nih.gov
Background Generally, small-cell lung cancer (SCLC) can be classified into central and
peripheral-type. Genomic landscape and genetic heterogeneity between central and …