Hydroxychloroquine in rheumatic autoimmune disorders and beyond

EL Nirk, F Reggiori, M Mauthe - EMBO molecular medicine, 2020 - embopress.org
Initially used as antimalarial drugs, hydroxychloroquine (HCQ) and, to a lesser extent,
chloroquine (CQ) are currently being used to treat several diseases. Due to its cost …

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

E Schrezenmeier, T Dörner - Nature Reviews Rheumatology, 2020 - nature.com
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Multifaceted effects of hydroxychloroquine in human disease

NJ Olsen, MA Schleich, DR Karp - Seminars in Arthritis and Rheumatism, 2013 - Elsevier
Objectives Hydroxychloroquine (HCQ) is a widely used medication for the treatment of
rheumatoid arthritis and systemic lupus erythematosus. An increasing body of evidence …

Mode of action of hydroxychloroquine in RA—evidence of an inhibitory effect on toll-like receptor signaling

D Kyburz, F Brentano, S Gay - Nature clinical practice Rheumatology, 2006 - nature.com
Antimalarial drugs have been used for many years to treat rheumatic diseases such as
rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The two most commonly …

Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand-related issue?

A Srinivasa, S Tosounidou, C Gordon - The Journal of rheumatology, 2017 - jrheum.org
Hydroxychloroquine (HCQ) is a well-established drug used in the treatment of systemic
lupus erythematosus (SLE). Lupus UK, a national registered charity supporting people who …

[HTML][HTML] Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases

ET Reis, AM Kakehasi, MM Pinheiro… - Advances in …, 2020 - SciELO Brasil
Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in
the treatment of rheumatic diseases and have recently become the focus of attention …

Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase

N Müller-Calleja, D Manukyan, A Canisius… - Annals of the …, 2017 - ard.bmj.com
Objectives Hydroxychloroquine (HCQ) has been used for decades to treat patients with
rheumatic diseases, for example, systemic lupus erythematosus (SLE), rheumatoid arthritis …

Clinical and structural efficacy of hydroxychloroquine in rheumatoid arthritis: a systematic review

C Rempenault, B Combe, T Barnetche… - Arthritis care & …, 2020 - Wiley Online Library
Objective Hydroxychloroquine (HCQ) improves metabolic and cardiovascular outcomes in
patients with rheumatoid arthritis (RA), but its efficacy appears to be moderate as compared …

Hydroxychloroquine in systemic lupus erythematosus: overview of current knowledge

A Dima, C Jurcut, F Chasset… - Therapeutic …, 2022 - journals.sagepub.com
The antimalarial hydroxychloroquine (HCQ) has demonstrated several crucial properties for
the treatment of systemic lupus erythematosus (SLE). Herein, we reviewed the main HCQ …

Hydroxychloroquine: the cornerstone of lupus therapy

G Ruiz-Irastorza, MA Khamashta - Lupus, 2008 - journals.sagepub.com
Tradition has it that in 1630, the Countess of Chinchon, the wife of the Spanish Viceroy of
Peru, was cured of fevers by a mysterious powder provided by a Jesuit priest. The powder …