Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
M Zhang, JL Luo, Q Sun, J Harber, AG Dawson… - Nature …, 2021 - nature.com
Abstract Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20–50 years after
exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate …
exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate …
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …
challenging clinical management. Through a large series of whole-genome sequencing …
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
R Bueno, EW Stawiski, LD Goldstein, S Durinck… - Nature …, 2016 - nature.com
Abstract We analyzed transcriptomes (n= 211), whole exomes (n= 99) and targeted exomes
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …
Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Background Malignant pleural mesothelioma (MPM) has a poor overall survival with few
treatment options. Whole genome sequencing (WGS) combined with the immune features of …
treatment options. Whole genome sequencing (WGS) combined with the immune features of …
[HTML][HTML] Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study
Introduction Malignant pleural mesothelioma (MPM) is a rare malignant disease, and the
understanding of molecular pathogenesis has lagged behind other malignancies. Methods …
understanding of molecular pathogenesis has lagged behind other malignancies. Methods …
[HTML][HTML] The genetic landscape of malignant pleural mesothelioma: results from massively parallel sequencing
M Hylebos, G Van Camp, JP Van Meerbeeck… - Journal of Thoracic …, 2016 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare yet aggressive tumor that is causally
associated with—mostly professional—asbestos exposure. Given the long latency between …
associated with—mostly professional—asbestos exposure. Given the long latency between …
Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm associated with
asbestos exposure. Although previous studies based on candidate gene approaches have …
asbestos exposure. Although previous studies based on candidate gene approaches have …
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling
GJ Gordon, GN Rockwell, RV Jensen… - The American journal of …, 2005 - Elsevier
Malignant pleural mesothelioma (MPM) is a highly lethal, poorly understood neoplasm that
is typically associated with asbestos exposure. We performed transcriptional profiling using …
is typically associated with asbestos exposure. We performed transcriptional profiling using …
Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
Y Blum, C Meiller, L Quetel, N Elarouci, M Ayadi… - Nature …, 2019 - nature.com
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …
Redefining malignant pleural mesothelioma types as a continuum uncovers immune-vascular interactions
N Alcala, L Mangiante, N Le-Stang, CE Gustafson… - …, 2019 - thelancet.com
Abstract Background Malignant Pleural Mesothelioma (MPM) is an aggressive disease
related to asbestos exposure, with no effective therapeutic options. Methods We undertook …
related to asbestos exposure, with no effective therapeutic options. Methods We undertook …