In this chapter we attempt to present a novel prodrug approach which is based on enzyme
models that have been advocated to understand the mechanism by which enzymes catalyze …

This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

The striking efficiency of enzyme catalysis has inspired many organic chemists to explore
enzyme mechanisms by studying certain intra molecular processes such as enzyme models …

Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

Enzymes are highly specific biological catalysts that accelerate the rate of chemical
reactions within the cell. Our knowledge of how enzymes work remains incomplete …

The conventional old treatment method for cancer therapy is associated with severe side
effects along with several limitations. Therefore, searching and developing new methods for …

Prodrugs, soft drugs, targeted drugs, and metabolites of drugs are common terms that are
used in the pharmaceutical field. The term “prodrug” was first introduced by Albert to signify …

DFT molecular orbital calculations at B3LYP 6-31G (d, p) and B3LYP/311+ G (d, p) levels
and molecular mechanics (MM2) calculations of kinetic properties for Bruice's systems 1-5 …

When knowledge fails to provide answers to important questions such as how to improve the
bioavailability of vital medications,“Imagination is more important than knowledge,” as Albert …

Prodrugs are designed to improve pharmaceutical/biopharmaceutical characteristics,
pharmacokinetic/pharmacodynamic properties, site-specificity, and more. A crucial step in …