The RNA helicase DDX39A binds a conserved structure in Chikungunya virus RNA to control infection

I Tapescu, F Taschuk, SM Pokharel, O Zginnyk… - Molecular Cell, 2023 - cell.com
Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

DDX56 binds to chikungunya virus RNA to control infection

F Taschuk, I Tapescu, RH Moy, S Cherry - MBio, 2020 - Am Soc Microbiol
ABSTRACT DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of
this family carry out essential cellular functions, and emerging literature is revealing …

The host DHX9 DExH-box helicase is recruited to chikungunya virus replication complexes for optimal genomic RNA translation

R Matkovic, E Bernard, S Fontanel, P Eldin… - Journal of …, 2019 - Am Soc Microbiol
Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by
various RNA viruses in order to assist replication of the viral genome. Here, we identify the …

Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein

G Chen, CH Liu, L Zhou, RM Krug - Cell host & microbe, 2014 - cell.com
Influenza A virus RNA synthesis is catalyzed by the viral polymerase comprised of the PA,
PB1, and PB2 proteins. We show that the host DDX21 RNA helicase restricts influenza A …

Structural basis of human helicase DDX21 in RNA binding, unwinding, and antiviral signal activation

Z Chen, Z Li, X Hu, F Xie, S Kuang, B Zhan… - Advanced …, 2020 - Wiley Online Library
RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the
regulation of host innate immunity during virus infection. How DDX21 recognizes and …

DEAD-box helicase DDX25 is a negative regulator of type I interferon pathway and facilitates RNA virus infection

T Feng, T Sun, G Li, W Pan, K Wang… - Frontiers in Cellular and …, 2017 - frontiersin.org
Dengue is a mosquito-borne viral disease that rapidly spread in tropic and subtropic area in
recent years. DEAD (Glu-Asp-Ala-Glu)-box RNA helicases have been reported to play …

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

YS Law, A Utt, YB Tan, J Zheng… - Proceedings of the …, 2019 - National Acad Sciences
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes
Chikungunya fever. Nonstructural protein 2 (nsP2) exhibits the protease and RNA helicase …

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity

F Valiente‐Echeverría, MA Hermoso… - Reviews in medical …, 2015 - Wiley Online Library
Summary Asp‐Glu‐Ala‐Asp (DEAD)‐box polypeptide 3, or DDX3, belongs to the DEAD‐box
family of ATP‐dependent RNA helicases and is known to play different roles in RNA …

DDX5 RNA helicases: emerging roles in viral infection

W Cheng, G Chen, H Jia, X He, Z Jing - International journal of molecular …, 2018 - mdpi.com
Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical
member of the large ATP-dependent RNA helicases family and is known to participate in all …

Targeting host DEAD-box RNA helicase DDX3X for treating viral infections

PT Winnard Jr, F Vesuna, V Raman - Antiviral research, 2021 - Elsevier
Abstract DDX3X or DDX3, a member of the DEAD (asp, glu, ala, asp) box RNA helicase
family of proteins, is a multifunctional protein, which is usurped by several viruses and is vital …