The 5-HT 3 receptor is a member of the Cys-loop family of ligandgated ion channels. The
extracellular domains of these proteins contain six amino acid loops (A–F) that converge to …

5-HT 3 receptors are members of the Cys loop family of ligand-gated ion channels. We used
the substituted cysteine accessibility method to identify amino acid residues in the channel …

Current receptor theory suggests that there is an equilibrium between the inactive (R) and
active (R*) conformations of ligand-gated ion channels and G protein-coupled receptors …

The ligand binding pocket of Cys-loop receptors consists of a number of binding loops
termed A–F. Here we examine the 5-HT3 receptor loop A residues Asn-128, Glu-129 and …

5-HT3A receptors are pentameric neurotransmitter-gated ion channels in the Cys-loop
receptor family. Each subunit contains an extracellular domain, four transmembrane …

Whole cell voltage clamp electrophysiology and radioligand binding were used to examine
the agonist characteristics of the two splice variants of the 5‐HT3 receptor which have been …

HT 3 receptors demonstrate significant structural and functional homology to other members
of the Cys-loop ligand-gated ion channel superfamily. The extracellular domains of these …

The 5-HT 3 receptor belongs to a family of therapeutically important neurotransmitter-gated
receptors whose ligand binding sites are formed by the convergence of six peptide loops …

A large cytoplasmic domain accounts for approximately one-third of the entire protein of one
superfamily of ligand-gated membrane ion channels, which includes nicotinic acetylcholine …

The binding sites of Cys-loop receptors are formed from at least six loops (A− F). Here we
have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and …