Celastrol, a compound extracted from traditional Chinese medicine, has been reported as a
potent anti-obesity agent with controversial mechanisms. Here both C57BL/6J and leptin …

Background Obesity has become one of the most serious issues threatening the health of
humankind, and we conducted this study to examine whether and how celastrol protects …

The antiobesity effect of celastrol has been reported in numerous studies, but the underlying
mechanism remains unclear. It is widely accepted that gut dysbiosis is closely related to …

Celastrol, a plant-derived constituent of traditional Chinese medicine, has been proposed to
offer significant potential as an antiobesity drug. However, the molecular mechanism for this …

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

This study aimed to evaluate the possible anti-obesity effects of orlistat and ezetimibe and
determine the mechanism by which they alter the composition of gut microbiota and short …

Despite all modern advances in medicine, an effective drug treatment of obesity has not
been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity …

Celastrol, a natural triterpene, has been shown to treat obesity and its related metabolic
disorders. In this study, we first assessed the relationship between the antiobesity effects of …

High-fat diet (HFD)-induced obesity is a risk factor for many metabolic disorders including
cardiovascular diseases, diabetes, and fatty liver disease. Although there are accumulating …

Stigmasterol (ST) has been shown to improve both lipid and bile acid (BA) metabolism.
However, the mechanism (s) by which ST prevents dyslipidemia via BA metabolism, and the …