Delivery and specificity of CRISPR/Cas9 genome editing technologies for human gene therapy

JL Gori, PD Hsu, ML Maeder, S Shen… - Human gene …, 2015 - liebertpub.com
Genome editing using the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR associated 9 (Cas9) technology is revolutionizing the study of gene …

[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - Signal transduction and …, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine

FV Jacinto, W Link, BI Ferreira - Journal of cellular and …, 2020 - Wiley Online Library
The recent development of the CRISPR/Cas9 system as an efficient and accessible
programmable genome‐editing tool has revolutionized basic science research …

Delivery of CRISPR/Cas9 for therapeutic genome editing

X Xu, T Wan, H Xin, D Li, H Pan, J Wu… - The journal of gene …, 2019 - Wiley Online Library
The clustered, regularly‐interspaced, short palindromic repeat (CRISPR)‐associated
nuclease 9 (CRISPR/Cas9) is emerging as a promising genome‐editing tool for treating …

Development and application of CRISPR/Cas9 technologies in genomic editing

C Zhang, R Quan, J Wang - Human molecular genetics, 2018 - academic.oup.com
Genomic editing to correct disease-causing mutations is a promising approach for the
treatment of human diseases. As a simple and programmable nuclease-based genomic …

[HTML][HTML] Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing

HA Han, JKS Pang, BS Soh - Journal of Molecular Medicine, 2020 - Springer
The rapid advancement of genome editing technologies has opened up new possibilities in
the field of medicine. Nuclease-based techniques such as the CRISPR/Cas9 system are …

[HTML][HTML] The potential of CRISPR/Cas9 gene editing as a treatment strategy for inherited diseases

SA Abdelnour, L Xie, AA Hassanin, E Zuo… - Frontiers in cell and …, 2021 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising
innovative technology for genomic editing that offers scientists the chance to edit DNA …

[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy

MF Rasul, BM Hussen, A Salihi, BS Ismael, PJ Jalal… - Molecular Cancer, 2022 - Springer
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

[HTML][HTML] Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

M Khoshandam, H Soltaninejad, M Mousazadeh… - Genes & …, 2024 - Elsevier
CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …

[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases

G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …