Despite the successful use of antibacterials, the emergence of multidrug-resistant bacteria
has become a serious threat to global healthcare. In this era of antibacterial crisis …

The alarming rise in antimicrobial resistance coupled with a lack of innovation in antibiotics
has renewed interest in the development of alternative therapies to combat bacterial …

Researchers increasingly believe that microbial, molecular and synthetic biology techniques
along with genetic engineering will facilitate the treatment of persistent infectious diseases …

Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …

The serious threats posed by drug-resistant bacterial infections and recent developments in
synthetic biology have fueled a growing interest in genetically engineered phages with …

Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth,
constituting a virtually unlimited resource to explore the development of biomedical …

The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Highlights•Synthetic biology enables efficient phage genome engineering.•Phages with
tunable host range and antimicrobial payload delivery enhance efficacy.•Phage design …

The use of engineered phages offers a unique opportunity to improve on wild-type (WT)
phages to generate ever more successful therapeutics to combat bacterial infections. Here …

The alarming spread of multiresistant infections has kick-started the quest for alternative
antimicrobials. In a way, given the steady increase in untreatable infectious diseases …