Background: Neurological disorders are composed of several diseases that affect the central
and peripheral nervous system; among these are neurodegenerative diseases, which lead …

For many years it was desirable one drug for one target disease', however, the researchers
observed that complex diseases are best addressed when treated with multi-targeted drugs …

Multi-target drug development (MTDD) is the demand of the recent era, especially in the
case of multi-factorial conditions such as cancer, depression, neurodegenerative diseases …

There are no therapeutic areas that are more pressing and frustrating than the neuro
degenerative diseases. This is not just a com mon feeling of those like us tirelessly work ing …

HIGHLIGHTS Many CNS targets are being explored for multi-target drug design New
databases and cheminformatic methods enable prediction of primary pharmaceutical target …

Individuals with neurodegenerative diseases such as Parkinson's disease or Alzheimer's
disease are benefiting from drugs developed to act on a single molecular target. However …

Neurodegenerative disorders lead to increased mortality and morbidity in older patients, and
are a great burden on society, where there is currently no approved treatment to prevent the …

In the present review, the authors provide the basic background about the molecular targets
implicated in the pathogenesis of Alzheimer's disease. Furthermore, the authors review …

Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …

Background: Neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic
lateral sclerosis, Parkinson's disease (PD), spinal cerebellar ataxias, and spinal and bulbar …