The renin-angiotensin-aldosterone system (RAAS) is a well-defined pathway playing a key
role in maintaining circulatory homeostasis. Abnormal activation of RAAS contributes to …

Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with
the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II …

Targeting angiotensinogen with RNA-based therapeutics is a promising new tool to treat
hypertension and diseases beyond. Their long-lasting effects are particularly exciting, and if …

The renin‐angiotensin system (RAS) plays a central role in cardiovascular homeostasis.
Angiotensin is the key peptide of the RAS, and exerts its influence on the heart and blood …

Despite the tremendous success obtained using the current pharmacotherapy, especially
angiotensin (Ang)-converting enzyme (ACE) inhibitors (ACEis) and Ang II receptor blockers …

Uncontrolled hypertension is an important contributor to cardiovascular disease. Despite the
armamentarium of antihypertensive treatments, there remains a need for novel agents …

Previous studies have reported that risk of cardiovascular morbidity and mortality
substantially increases in hypertensive patients, especially among those with inadequate …

As part of the systemic circulating human renin–angiotensin system, angiotensin 1-
converting enzyme (ACE) degrades (vasodilator) kinins and generates (vasoconstrictor) …

Atherosclerosis and its vascular sequela are responsible for considerable morbidity and
mortality rates. Several risk factors have been implicated in the pathogenesis of …

Angiotensinogen (AGT) is the unique precursor of all angiotensin peptides. Many of the
basic understandings of AGT in cardiovascular diseases have come from research efforts to …