The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Zygotic genome activation (ZGA) is a nuclear reprogramming event that transforms the
genome from transcriptional quiescence at fertilization to robust transcriptional activity …

A defining feature of early embryogenesis is the transition from maternal to zygotic control.
This transition requires embryo-wide zygotic genome activation (ZGA), but the extent of …

Zygotic genome activation (ZGA) denotes the initiation of gene expression after fertilization.
It is part of the complex oocyte-to-embryo transition (OET) in which a highly specialized cell …

Zygotic gene activation (ZGA) is the first event of gene expression after fertilization.
Following fertilization, ZGA occurs within a short time interval depending on the animal …

Activation of transcription within the embryonic genome (EGA) after fertilization is a complex
process requiring a carefully coordinated series of nuclear and cytoplasmic events, which …

The transition from maternal to zygotic control is fundamental to the life cycle of all
multicellular organisms. It is widely believed that genomes are transcriptionally inactive from …

After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …

Cellular transitions occur at all stages of organismal life from conception to adult
regeneration. Changing cellular state involves three main features: activating gene …