Background Biological factors are known to influence disease trajectories and treatment
effectiveness in alcohol addiction and preclinical and clinical evidence suggests that sex is …

Background: Epidemiological studies suggest that initiation of alcohol drinking at an early
age is associated with an increased risk of developing an alcohol use disorder later in life …

Background: Alcoholism is characterized by compulsive alcohol intake, but this critical
feature of alcoholism is seldom captured in preclinical studies. Here, we evaluated whether …

Alcohol use disorder (AUD) is a chronically relapsing disorder, characterized by a shift from
casual to compulsive intake of alcohol that is driven by changes in multiple regions …

Alcohol use disorder (AUD) is characterized by excessive and persistent alcohol use,
despite adverse consequences. AUD often originates during adolescence, as do other …

Alcohol use is one of the world's leading causes of death and disease, although only a small
proportion of individuals develop persistent alcohol use disorder (AUD). The identification of …

The use of mice in alcohol research provides an excellent model system for a better
understanding of the genetics and neurobiology of alcohol addiction. Almost 60 years ago …

We previously reported that commercially-sourced C57BL/6J (B6) male mice with a history
of adult-onset binge-drinking exhibit anxiety-like behavior in early withdrawal, while the …

Background Binge alcohol drinking is a risk factor linked to numerous disease states
including alcohol use disorder (AUD). While men binge drink more alcohol than women, this …

Background Alcohol use disorder is a serious illness marked by uncontrollable drinking and
a negative withdrawal state when not using. Alcohol is one of the most commonly used …