Biology and therapeutic targets of colorectal serrated adenocarcinoma; clues for a histologically based treatment against an aggressive tumor

B Alburquerque-González, FF López-Calderón… - International Journal of …, 2020 - mdpi.com
Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological
subtype accounting for around 9% of colorectal carcinomas. Compared to conventional …

Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma

P Conesa‐Zamora, J García‐Solano… - … journal of cancer, 2013 - Wiley Online Library
Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype
accounting for 7.5 to 8.7% of CRCs. It has been shown that SAC has a poorer prognosis and …

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

P Laiho, A Kokko, S Vanharanta, R Salovaara… - Oncogene, 2007 - nature.com
Serrated colorectal carcinomas (CRCs) are morphologically different from conventional
CRCs and have been proposed to follow a distinct pathway of CRC formation. Despite …

Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes

D Hirano, Y Urabe, S Tanaka, K Nakamura… - Plos one, 2019 - journals.plos.org
Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia
pathway. Although SAC prognosis is not widely recognized, the serrated pathway …

Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition

S Gurzu, Z Szentirmay, E Toth, T Bara, T Bara Jr… - PLoS …, 2013 - journals.plos.org
Introduction Colorectal adenocarcinomas (CRC) developed through serrated pathway seem
to present particular behavior compared with the non-serrated ones, but recognition of them …

Clinical, pathological genetics and intratumoral immune milieu of serrated adenocarcinoma of the colon

O Yılmaz, A Crabbe, A Neyaz, A Pankaj… - …, 2022 - Wiley Online Library
Background Serrated adenocarcinoma (SAC), a recognised WHO variant of colonic
adenocarcinoma, is the purported end‐product of serrated neoplasia. However, the …

VE1 immunohistochemistry accurately detects BRAF V600E mutations in colorectal carcinoma and can be utilized in the detection of poorly differentiated colorectal …

S Sajanti, P Sirniö, JP Väyrynen, A Tuomisto, K Klintrup… - Virchows Archiv, 2014 - Springer
Serrated adenocarcinoma (SAC) is a recently defined subtype of colorectal carcinoma
(CRC). However, in cases where an adjacent serrated adenoma is absent and the …

Serrated colorectal cancer: Preclinical models and molecular pathways

A Aiderus, N Barker, V Tergaonkar - Trends in Cancer, 2023 - cell.com
Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …

Serrated colorectal cancer: the road less travelled?

Y Nakanishi, MT Diaz-Meco, J Moscat - Trends in cancer, 2019 - cell.com
Studies of colorectal cancer (CRC) originating through the conventional adenoma-
carcinoma sequence have provided insight into the molecular mechanisms controlling its …

[HTML][HTML] Molecular features of the serrated pathway to colorectal cancer: current knowledge and future directions

C Satorres, M García-Campos… - Gut and Liver, 2021 - ncbi.nlm.nih.gov
Serrated lesions are the precursor lesions of a new model of colorectal carcinogenesis.
From a molecular standpoint, the serrated pathway is thought to be responsible for up to …