Fixed-drug combinations have been used for the treatment of cancer. Current anticancer
therapies, however, tend to induce resistance and provoke important toxicity. Therefore …

New drugs and technologies are continuously developed to improve the efficacy and
minimize the critical side effects of cancer treatments. The present investigation focuses on …

Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable
method to treat various diseases with a broad range of biological activity; however …

Histone deacetylase (HDAC) inhibitors (HDACi) of the class I trichostatin A (TSA), CG1521
(CG), and PXD101 (PXD) were incorporated at a high rate (∼ 1mM) in liposomes made of …

Histone modification that occurs through the process of acetylation plays a key role in the
epigenetic regulation of gene expression. The balance between histone deacetylases …

Cancer is one of the leading causes of death, and latest predictions indicate that cancer-
related deaths will increase over the next few decades. Despite significant advances in …

Drug therapy for many pathologies relies on the combination of multiple drugs. An
interesting approach is their combination in the same nanocarrier. When drugs that were …

Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-
cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite …

The present study aims to develop a delivery system that can carry small interference RNA
(siRNA) with small-molecule chemotherapeutic drugs, which can be used in cancer …

Cancer treatment is an area of ongoing concern and requires a great deal of research in
order to provide patients and providers with the best possible therapeutic options …