Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

Simple Summary Cancer stem cell (CSC) directed therapies have been increasingly
developed during the last years. However, some reported experiments using this strategy …

Many tumors derive from the transformation of normal stem cells into cancer stem-cells that
retain their self-renewal capacity. This modern view of cancer has provided a natural …

The recently developed concept of cancer stem cells (CSC) sheds new light on various
aspects of tumor growth and progression. Here, we present a mathematical model of …

The involvement of Cancer Stem Cells (CSCs) in tumor progression and tumor recurrence is
one of the most studied subjects in current cancer research. The CSC hypothesis states that …

Background The Cancer Stem Cell (CSC) hypothesis has gained credibility within the
cancer research community. According to this hypothesis, a small subpopulation of cells …

The cancer stem cell hypothesis has evolved into one of the most important paradigms in
cancer research. According to cancer stem cell hypothesis, somatic mutations in a …

Cancer stem cells (CSCs) drive tumor progression, metastases, treatment resistance, and
recurrence. Understanding CSC kinetics and interaction with their nonstem counterparts …

Cancer stem cells (CSCs) are key in understanding tumor growth and tumor progression. A
counterintuitive effect of CSCs is the so-called tumor growth paradox: the effect where a …

The cancer stem cell hypothesis suggests that tumors contain a small population of cancer
cells that have the ability to undergo symmetric self-renewing cell division. In tumors that …