V2a interneurons are located in the hindbrain and spinal cord, where they provide rhythmic
input to major motor control centers. Many of the phenotypic properties and functions of …

The spinal cord consists of multiple neuronal cell types that are critical to motor control and
arise from distinct progenitor domains in the developing neural tube. Excitatory V2a …

Challenges in parsing specific contributions to spinal microcircuit architecture have limited
our ability to model and manipulate those networks for improved functional regeneration …

Abstract Introduction Spinal V3 interneurons (INs) are a commissural, glutamatergic,
propriospinal neuron population that holds great potential for understanding locomotion …

V2a interneurons of the ventral spinal cord and hindbrain play an important role in the
central pattern generators (CPGs) involved in locomotion, skilled reaching, and respiration …

V3 interneurons (INs) are a major group of excitatory commissural interneurons in the spinal
cord, and they are essential for producing a stable and robust locomotor rhythm. V3 INs are …

Cellular replacement therapies for neurological conditions use human embryonic stem cell
(hESC)-or induced pluripotent stem cell (hiPSC)-derived neurons to replace damaged or …

In this issue, Maroof et al.(2013) and Nicholas et al.(2013) describe strategies for deriving
cortical interneurons from human pluripotent stem cells. Functional maturation of these …

Excitatory commissural V3 interneurons (INs) of the ventral spinal cord have been shown to
balance locomotor rhythm regularity and robustness in vivo. Unfortunately, due to the …

Abstract Chx10-expressing V2a (Chx10+ V2a) spinal interneurons play a large role in the
excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the …