Background & Aims Hepatic stellate cells (HSCs) play a key role in liver fibrosis in various
chronic liver disorders including nonalcoholic fatty liver disease (NAFLD). The development …

Non-alcoholic fatty liver disease (NAFLD) is a broad spectrum of liver damage disease from
a simple fatty liver (steatosis) to more severe liver conditions such as non-alcoholic …

Background & Aims Clinical evidence has indicated a close link between non-alcoholic fatty
liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying …

Liver fibrosis occurs in response to chronic liver injury and is characterized by an excessive
deposition of extracellular matrix. Activated hepatic stellate cells are primarily responsible for …

Extracellular vesicles (EVs) have been growingly recognized as biomarkers and mediators
of alcoholic liver disease (ALD) in human and mice. Here we characterized hepatocyte …

Liver fibrosis is a severe stage of nonalcoholic fatty liver disease (NAFLD), which is closely
associated with the activation of hepatic stellate cells (HSCs) and their interaction with …

Liver fibrosis is characterized by the activation and migration of hepatic stellate cells (HSCs),
followed by matrix deposition. Recently, several studies have shown the importance of …

Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the
underlying mechanisms of this association have not been clarified. We aimed to elucidate …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but
the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis …