Numerous studies, both in enzymatic and nonenzymatic catalysis, have been undertaken to
understand the way by which metal ions, especially zinc ions, promote the hydrolysis of …

More and more frequently, catalytic systems based around two metal ions are reported in
chemistry (eg, Sharpless epoxidation, Corey's chemzyme) and in biology (eg, methane …

Metabolic and signaling biochemical pathways have numerous steps that involve the
hydrolytic cleavage of peptide or phosphate ester bonds. Although both types of bonds are …

At least one-third of enzymes contain metal ions as cofactors necessary for a diverse range
of catalytic activities. In the case of polymetallic enzymes (ie, two or more metal ions involved …

Many nuclease and peptidase enzymes achieve highly efficient catalysis by active site
cooperation of metal ions and amino acid side chains (acids, bases or nucleophiles). This …

7214 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. Chem. 2006, 118,
7214–7217 these conditions.[2] Inspired by the structures of dinuclear metalloenzymes,[3] …

Nucleophilic attack of the bridging oxo ligand is the key step in the hydrolysis of the bridging
phosphate diester in complex 1. This hydrolysis is 10 12 times faster than the hydrolysis of …

Nucleases catalyze hydrolytic cleavage of the phosphodiester backbone of DNA and RNA,
remarkable chemistry given the stability of the phosphodiester bond. 1 Eventhe activated …

Recently there has been great interest in designing small metal complexes which are
capable of catalytically hydrolyzing deoxyribonucleic acid (DNA), ribonucleic acid (RNA) …

The copper (II) complexes [(L n) Cu (NO3) 4⊙ 2 (H2O)](n= 1: 1, n= 2: 2) of the ammonium-
functionalized ligands [6, 6 '-(Me2HNCH2C⋮ C) 2bpy] 2+(L 1) and [6, 6 '-(Me3NCH2C⋮ C) …