Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein-DNA-PK
K Shaheer, BRS Prabhu, HS Ali, D Lakshmanan-M - Phytomedicine, 2024 - Elsevier
Background Non-homologous end joining, an important DNA-double-stranded break repair
pathway, plays a prominent role in conferring resistance to radiotherapeutic agents …
pathway, plays a prominent role in conferring resistance to radiotherapeutic agents …
Piperine sensitizes radiation‐resistant cancer cells towards radiation and promotes intrinsic pathway of apoptosis
K Shaheer, HM Somashekarappa… - Journal of Food …, 2020 - Wiley Online Library
Piperine, a bioactive alkaloid, is known to have anticancer activities. Hence, in this study, the
effectiveness of piperine pretreatment as a strategy for radio‐sensitizing colorectal …
effectiveness of piperine pretreatment as a strategy for radio‐sensitizing colorectal …
[HTML][HTML] Synergistic radiosensitizing effect of BR101801, a specific DNA-dependent protein kinase inhibitor, in various human solid cancer cells and xenografts
JH Lee, B Jeon, M Park, J Ha, SJ Kim… - American Journal of …, 2021 - ncbi.nlm.nih.gov
DNA-dependent protein kinase (DNA-PK), an essential component of the non-homologous
end-joining (NHEJ) repair pathway, plays an important role in DNA damage repair (DDR) …
end-joining (NHEJ) repair pathway, plays an important role in DNA damage repair (DDR) …
Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro
EM Nolte, AM Joubert, L Lafanechère… - International Journal of …, 2023 - mdpi.com
Radiation resistance and radiation-related side effects warrant research into alternative
strategies in the application of this modality to cancer treatment. Designed in silico to …
strategies in the application of this modality to cancer treatment. Designed in silico to …
Effect of low dose of berberine on the radioresistance of cervical cancer cells via a PI3K/HIF-1 pathway under nutrient-deprived conditions
X Zeng, L Wan, Y Wang, J Xue, H Yang… - International Journal of …, 2020 - Taylor & Francis
Purpose: Radiotherapy (RT) is one of the major treatments of cervical cancer. Although the
prognosis of clinical cervical cancer becomes better in recent years, some patients still suffer …
prognosis of clinical cervical cancer becomes better in recent years, some patients still suffer …
Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair
J Dong, Y Ren, T Zhang, Z Wang… - Oncology …, 2018 - spandidos-publications.com
The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in non-
homologous end-joining (NHEJ) repair. We investigated the mechanism of NU7441, a …
homologous end-joining (NHEJ) repair. We investigated the mechanism of NU7441, a …
Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells
S Khozooei, K Lettau, F Barletta, T Jost… - Journal of Experimental …, 2022 - Springer
Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …
SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells
A Güttler, C Weinholdt, E Ruff, J Reidt, E Darnstaedt… - Cells, 2022 - mdpi.com
Betulinic acid (BA) is a natural compound well known for its anti-inflammatory, anti-viral, anti-
bacterial, anti-malarial effects and anti-tumor properties. Its enhanced cytotoxicity in tumor …
bacterial, anti-malarial effects and anti-tumor properties. Its enhanced cytotoxicity in tumor …
The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events
S Timilsina, S Rajamanickam, A Rao, P Subbarayalu… - Cancer letters, 2022 - Elsevier
Aberrant activities of various cell cycle and DNA repair proteins promote cancer growth and
progression and render them resistant to therapies. Here, we demonstrate that the anti …
progression and render them resistant to therapies. Here, we demonstrate that the anti …
Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells
DNA-dependent protein kinase (DNA-PK) plays a pivotal role in the repair of DNA double-
strand breaks (DSB) and is centrally involved in regulating cellular radiosensitivity. Here, we …
strand breaks (DSB) and is centrally involved in regulating cellular radiosensitivity. Here, we …