Inflammasome activation is an innate host defense mechanism initiated upon sensing
pathogens or danger in the cytosol. Both autophagy and cell death are cell autonomous …

When microbes contaminate the macrophage cytoplasm, leukocytes undergo a
proinflammatory death that is initiated by nucleotide-binding-domain-, leucine-rich-repeat …

Inflammation plays a significant role in protecting hosts against pathogens. Inflammation
induced by noninfectious endogenous agents can be detrimental and, if excessive, can …

Two of the main challenges that multicellular organisms faced during evolution were to cope
with invading microorganisms and eliminate and replace dying cells. Our innate immune …

Significance: The autophagy and inflammasome pathways are ancient innate immune
mechanisms for controlling invading pathogens that are linked by mutual regulation. In …

Inflammation is a defensive response of the organism to manage harmful stimuli sensed by
innate immune cells. The signal alarm is triggered by the recognition of pathogen …

Autophagy and inflammasome complex assembly are physiological processes that control
homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway that degrades …

Highlights•Pyroptosis is a form of programmed cell death that is lytic and pro-inflammatory.•
Pyroptosis occurs after caspase-1 or caspase-11 activation.•ASC can trigger pyroptosis via …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …