Air− liquid Interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions
D Baldassi, B Gabold, OM Merkel - Advanced nanobiomed …, 2021 - Wiley Online Library
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
[HTML][HTML] Air-liquid interface (ALI) impact on different respiratory cell cultures
The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
Recent advances in human respiratory epithelium models for drug discovery
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
[HTML][HTML] Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors
Abstract Development of an anti-SARS-CoV-2 therapeutic is hindered by the lack of
physiologically relevant model systems that can recapitulate host-viral interactions in human …
physiologically relevant model systems that can recapitulate host-viral interactions in human …
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …
In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease
N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …
put scientist and pharmaceutical companies worldwide on the spot to develop novel …
In vitro models for studying respiratory host–pathogen interactions
Respiratory diseases and lower respiratory tract infections are among the leading cause of
death worldwide and, especially given the recent severe acute respiratory syndrome …
death worldwide and, especially given the recent severe acute respiratory syndrome …
Human pulmonary 3D models for translational research
K Zscheppang, J Berg, S Hedtrich… - Biotechnology …, 2018 - Wiley Online Library
Lung diseases belong to the major causes of death worldwide. Recent innovative
methodological developments now allow more and more for the use of primary human …
methodological developments now allow more and more for the use of primary human …
Air–liquid interface culture of human and mouse airway epithelial cells
D Jiang, N Schaefer, HW Chu - Lung Innate Immunity and Inflammation …, 2018 - Springer
Air–liquid interface culture enables airway epithelial cells to differentiate into a
pseudostratified cell layer, consisting of ciliated cells, goblet/secretory cells, and basal cells …
pseudostratified cell layer, consisting of ciliated cells, goblet/secretory cells, and basal cells …
Culturing of human nasal epithelial cells at the air liquid interface
L Müller, LE Brighton, JL Carson, WA Fischer II… - JoVE (Journal of …, 2013 - jove.com
In vitro models using human primary epithelial cells are essential in understanding key
functions of the respiratory epithelium in the context of microbial infections or inhaled agents …
functions of the respiratory epithelium in the context of microbial infections or inhaled agents …