[HTML][HTML] Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

[HTML][HTML] Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

[HTML][HTML] Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact

WA da Silveira, H Fazelinia, SB Rosenthal, EC Laiakis… - Cell, 2020 - cell.com
Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …

[HTML][HTML] The challenge of maintaining a healthy microbiome during long-duration space missions

AA Voorhies, HA Lorenzi - Frontiers in Astronomy and Space …, 2016 - frontiersin.org
Astronauts will face a host of challenges on long-duration space missions like a human
expedition to Mars, including the difficulty of maintaining a balanced and healthy …

[HTML][HTML] Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

AA Voorhies, C Mark Ott, S Mehta, DL Pierson… - Scientific Reports, 2019 - nature.com
Over the course of a mission to the International Space Station (ISS) crew members are
exposed to a number of stressors that can potentially alter the composition of their …

A Second Space Age Spanning Omics, Platforms, and Medicine Across Orbits

CE Mason, J Green, KI Adamopoulos, EE Afshin… - Nature, 2024 - nature.com
The recent acceleration of commercial, private, and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit (LEO), concomitant with the highest-ever …

[HTML][HTML] Space radiation: the number one risk to astronaut health beyond low earth orbit

JC Chancellor, GBI Scott, JP Sutton - Life, 2014 - mdpi.com
Projecting a vision for space radiobiological research necessitates understanding the nature
of the space radiation environment and how radiation risks influence mission planning …

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

FE Garrett-Bakelman, M Darshi, SJ Green, RC Gur… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

EG Overbey, JK Kim, BT Tierney, J Park, N Houerbi… - Nature, 2024 - nature.com
Spaceflight induces molecular, cellular, and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …

[HTML][HTML] Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …