Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza

W Cao, Y Wang, M Shi, X Hao, W Zhao… - Frontiers in Plant …, 2018 - frontiersin.org
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of
cardiovascular diseases. WRKYs play important roles in plant metabolism, but their …

Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots

C Deng, X Hao, M Shi, R Fu, Y Wang, Y Zhang, W Zhou… - Plant Science, 2019 - Elsevier
Tanshinones are the main bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used
for treating cardiovascular and cerebrovascular diseases. However, the biosynthetic …

Transcriptional Profiles of SmWRKY Family Genes and Their Putative Roles in the Biosynthesis of Tanshinone and Phenolic Acids in Salvia miltiorrhiza

H Yu, W Guo, D Yang, Z Hou, Z Liang - International Journal of Molecular …, 2018 - mdpi.com
Salvia miltiorrhiza Bunge is a Chinese traditional herb for treating cardiovascular and
cerebrovascular diseases, and tanshinones and phenolic acids are the dominated …

Integrated transcriptomics and proteomics to reveal regulation mechanism and evolution of SmWRKY61 on tanshinone biosynthesis in Salvia miltiorrhiza and Salvia …

Y Chen, Y Wang, J Guo, J Yang, X Zhang… - Frontiers in plant …, 2022 - frontiersin.org
Tanshinones found in Salvia species are the main active compounds for the treatment of
cardiovascular and cerebrovascular diseases, but their contents are hugely different in …

Molecular cloning and expression analysis of WRKY transcription factor genes in Salvia miltiorrhiza

C Li, D Li, F Shao, S Lu - BMC genomics, 2015 - Springer
Background WRKY proteins comprise a large family of transcription factors and play
important regulatory roles in plant development and defense response. The WRKY gene …

A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza

M Shi, R Zhu, Y Zhang, S Zhang, T Liu, K Li, S Liu… - Metabolic …, 2022 - Elsevier
Phenolic acids and tanshinones are main bioactive compounds produced in Salvia
miltiorrhiza widely used in treatment of cardiovascular diseases, which could be promoted …

Overexpression of SmbHLH10 enhances tanshinones biosynthesis in Salvia miltiorrhiza hairy roots

B Xing, D Yang, H Yu, B Zhang, K Yan, X Zhang, R Han… - Plant Science, 2018 - Elsevier
The bHLH transcription factors have important role in regulation of plant growth,
development, and secondary metabolism. Tanshinones are the major pharmaceutical …

Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures

G Kai, P Liao, H Xu, J Wang, C Zhou, W Zhou… - Acta Physiologiae …, 2012 - Springer
To develop an optimal bioprocess for the production of tanshinone which is mainly used for
the treatment of cardiocerebral vascular disease, the tanshinone biosynthetic pathway …

Molecular cloning and characterization of two 1-deoxy-d-xylulose-5-phosphate synthase genes involved in tanshinone biosynthesis in Salvia miltiorrhiza

W Zhou, F Huang, S Li, Y Wang, C Zhou, M Shi… - Molecular …, 2016 - Springer
The synthesis of diterpenoid tanshinones, which are some of the main bioactive ingredients
of Danshen (the roots of Salvia miltiorrhiza), begins with the plastidial methylerythritol 4 …

The SmMYB36-SmERF6/SmERF115 module regulates the biosynthesis of tanshinones and phenolic acids in salvia miltiorrhiza hairy roots

Q Li, X Fang, Y Zhao, R Cao, J Dong… - Horticulture …, 2023 - academic.oup.com
Tanshinone and phenolic acids are the most important active substances of Salvia
miltiorrhiza, and the insight into their transcriptional regulatory mechanisms is an essential …