Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
Many human genes have adapted to the constant threat of exposure to infectious agents;
according to the “hygiene hypothesis,” lack of exposure to parasites in modern settings …
according to the “hygiene hypothesis,” lack of exposure to parasites in modern settings …
Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies
K Vandenbroeck - Journal of Interferon & Cytokine Research, 2012 - liebertpub.com
Cytokine (receptor) genes have traditionally attracted great interest as plausible genetic risk
factors for autoimmune disease. Since 2007, the implementation of genome-wide …
factors for autoimmune disease. Since 2007, the implementation of genome-wide …
The genetics and immunopathogenesis of inflammatory bowel disease
JH Cho - Nature Reviews Immunology, 2008 - nature.com
Genome-wide association studies efficiently and powerfully assay common genetic
variation. The application of these studies to Crohn's disease has provided insight into the …
variation. The application of these studies to Crohn's disease has provided insight into the …
[HTML][HTML] Understanding inflammatory bowel disease via immunogenetics
KM de Lange, JC Barrett - Journal of autoimmunity, 2015 - Elsevier
The major inflammatory bowel diseases, Crohn's disease and ulcerative colitis, are both
debilitating disorders of the gastrointestinal tract, characterized by a dysregulated immune …
debilitating disorders of the gastrointestinal tract, characterized by a dysregulated immune …
From genetics of inflammatory bowel disease towards mechanistic insights
DB Graham, RJ Xavier - Trends in immunology, 2013 - cell.com
Advancements in human genetics now poise the field to illuminate the pathophysiology of
complex genetic disease. In particular, genome-wide association studies (GWAS) have …
complex genetic disease. In particular, genome-wide association studies (GWAS) have …
[HTML][HTML] Complex host genetics influence the microbiome in inflammatory bowel disease
Background Human genetics and host-associated microbial communities have been
associated independently with a wide range of chronic diseases. One of the strongest …
associated independently with a wide range of chronic diseases. One of the strongest …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …
association studies. To advance gene discovery further, we combined data from three …
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC), and
type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility …
type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility …
[HTML][HTML] Genetic variants regulating immune cell levels in health and disease
The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …
to defend against pathogens, but inadvertent immune system attacks on" self" result in …
[HTML][HTML] Genetic diversity in cytokines associated with immune variation and resistance to multiple pathogens in a natural rodent population
Pathogens are believed to drive genetic diversity at host loci involved in immunity to
infectious disease. To date, studies exploring the genetic basis of pathogen resistance in the …
infectious disease. To date, studies exploring the genetic basis of pathogen resistance in the …