Metabolic engineering reprograms cells to synthesize value-added products. In doing so,
endogenous genes are altered and heterologous genes can be introduced to achieve the …

Metabolic engineering is generally focused on static optimization of cells to maximize
production of a desired product, though recently dynamic metabolic engineering has …

Highlights•Two dynamic control modalities have been developed for metabolic
engineering.•The most common modality uses two phases of fermentation: growth and …

Highlights•Engineered cell experiences metabolic imbalance with reduced fitness.•
Overproduction phenotype requires dynamic redistribution of cellular resource.•Metabolite …

Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Highlights•Synthetic biology provides new tools for the dynamic control of
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …

The dynamic regulation of metabolic pathways is based on changes in external signals and
endogenous changes in gene expression levels and has extensive applications in the field …

Metabolic engineering strategies have enabled improvements in yield and titer for a variety
of valuable small molecules produced naturally in microorganisms, as well as those …

Maximizing the production of a desired small molecule is one of the primary goals in
metabolic engineering. Recent advances in the nascent field of synthetic biology have …

Metabolic engineering is often centred on rewiring cellular metabolism to improve the
production of chemicals. Turning cells into efficient factories is challenging because of …