A form of α-galactosylceramide, KRN7000, activates CD1d-restricted Vα14-invariant (Vα14i)
natural killer (NK) T cells and initiates multiple downstream immune reactions. We report that …

In spite of their relatively limited antigen receptor repertoire, CD1d-restricted NKT cells
recognize a surprisingly diverse range of lipid and glycolipid antigens. Recent studies of …

α-Galactosylceramide (α-GalCer) is the prototype compound for studying the presentation of
glycolipids on CD1d molecules to natural killer T (NKT) lymphocytes. A single iv dose of …

Abstract α-Galactosylceramide represents a new class of vaccine adjuvants and
immunomodulators that stimulate NKT cells to secrete Th1 and Th2 cytokines. Synthetic …

Certain glycolipid Ags for Vα14i NKT cells can direct the overall cytokine balance of the
immune response. Th2-biasing OCH has a lower TCR avidity than the most potent agonist …

α-Galactosylceramide (α-GalCer), a glycolipid that stimulates natural killer T (NKT) cells to
produce both T helper (Th) 1 and Th2 cytokines, has shown antitumor effects in mice but …

Certain types of glycolipids have been found to have remarkable immunomodulatory
properties as a result of their ability to activate specific T lymphocyte populations with an …

The glycolipid α-galactosylceramide (α-GalCer) has been shown to bind CD1d molecules to
activate invariant natural killer T (i NKT) cells, and subsequently induce activation of various …

Natural killer (NK) T cells with an invariant Vα14 rearrangement (Vα14 i) are the largest
population of lipid antigen-specific T lymphocytes identified in animals. They react to the …

Natural killer (NK) T cells are a lymphocyte subset with a distinct surface phenotype, an
invariant T cell receptor (TCR), and reactivity to CD1. Here we show that mouse NK T cells …