Mitochondrial cholesterol accumulation is a hallmark of alcoholic and non-alcoholic fatty
liver diseases and impairs the function of specific solute carriers through changes in …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …

Alcoholic liver disease (ALD) is a major cause of chronic liver disease and a growing health
concern in theworld. While the pathogenesis of ALD is poorly characterized key players …

Non‐alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of
histopathological changes ranging from non‐inflammatory intracellular fat deposition to non …

Mitochondria require cholesterol for biogenesis and membrane maintenance, and for the
synthesis of steroids, oxysterols and hepatic bile acids. Multiple pathways mediate the …

Mitochondria empower the liver to regulate lipid homeostasis by enabling fatty acid
oxidation during starvation and lipogenesis during nutrient-rich conditions. It is unknown if …

Cardiac phospholipids, notably cardiolipin, undergo acyl chain remodeling and/or loss of
content in aging and cardiovascular diseases, which is postulated to mechanistically impair …

Mitochondrial network architecture plays a critical role in cellular physiology. Indeed,
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …

Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

For decades, lipids were assumed to fulfill roles only in energy storage and membrane
structure. Recent studies have discovered critical roles for phospholipids, sphingolipids, and …